Neurolipidomics

Metabolic dysfunctions are not only highly correlated with insulin resistance and diabetes, but are also associated with a 10 fold higher risk to develop Alzheimer’s disease. The proposed project joins forces between two Leibniz institutions with different expertise to establish a unique research platform for Translational Neuroscience. Here, we will break ground by introducing lipidomics to the field of synapse biology, by investigating insulin resistance in conjunction with high Abeta­load and by studying the effect whether synaptic disease states result in an altered lipid composition that in turn leads to synaptic dysfunction in brain.

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