The lipidomics workflow


Even with a lipid content of over 10% in the human body, lipids were not in the central scientific focus during the last decade. However, more and more evidence is provided that non-genetically determined biomolecules such as metabolites and lipids are the key to biomolecular regulation. Today it is obvious that lipids are not only important for energy homeostasis and as an environmental-cellular barrier, but also represent a central part of our signal transduction machinery. Disruptions of the sensitive lipid metabolism are highly correlated with different types of diseases including thrombocytopenia, metabolic syndrome, diabetes, obesity and hyperlipidemia. This is especially true for the latter ones, which are also reaching pandemic levels, causing a larger annual health burden than infectious diseases. Therefore, lipid metabolism is again becoming an emerging scientific field and is a central part of pharmacological research today (statins, cyclooxygenase inhibitors, endurobol in doping). Thus, the mission of the Lipidomics group at ISAS is to understand the lipids in context with their proteins (enzymes) and building blocks (metabolites) in a true systems biology way.


Lipidomics needs Standardization

LSI Great, our Lipidomics Standard Initiative manuscript (LSI) is out! Thanks to all people and groups how supported this endeavor, ...
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LipoSysMed 2019

Turning hay into needles: the road to integration of large-scale analytical lipidomics data into biomedical research Lipidomics studies networks, pathways ...
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de.NBI Lipidomics

Lipidomics encompasses analytical approaches that aim to identify and quantify the complete set of lipids, defined as lipidome in a ...
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Metabolic dysfunctions are not only highly correlated with insulin resistance and diabetes, but are also associated with a 10 fold ...
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Phenotypes at cellular and organism level are a result of a multitude of different molecular species. Thereby, interconnected networks are ...
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de.NBI Proteomics

Computational proteomics is a constantly growing field to support end users with powerful and reliable tools for performing several computational ...
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Integrative biology

The study of complex biological systems is best approached by incorporating many perspectives. Thus omics strategies are the perfect toolset ...
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e:Med SUPR-G

Diffuse gliomas are the most frequent primary human brain tumors with glioblastoma being the most aggressive among them. The mean ...
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